Does experience change the actual structure of the brain?
Yes. Brain development is "activity-dependent," meaning that the electrical activity in every circuit—sensory, motor, emotional, cognitive—shapes the way that circuit gets put together.
Like computer circuits, neural circuits process information through the flow of electricity. Unlike computer circuits, however, the circuits in our brains are not fixed structures. Every experience–whether it is seeing one’s first rainbow, riding a bicycle, reading a book, sharing a joke–excites certain neural circuits and leaves others inactive. Those that are consistently turned on over time will be strengthened, while those that are rarely excited may be dropped away. Or, as neuroscientists sometimes say, “Cells that fire together, wire together.” The elimination of unused neural circuits, also referred to as “pruning,” may sound harsh, but it is generally a good thing. It streamlines children’s neural processing, making the remaining circuits work more quickly and efficiently. Without synaptic pruning, children wouldn’t be able to walk, talk, or even see properly.
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One of the most sensitive periods in brain development occurs at the very beginning, when the neural tube is closing.
Generally speaking, the central nervous system (which is composed of the brain and the spinal cord) matures in a sequence from "tail" to head.